Lowdermilk is a surname. Notable people with the surname include:
Brian Lowdermilk, American musical theater composerDwayne Lowdermilk (born 1958), Canadian ice hockey playerGrover Lowdermilk (1885–1968), American baseball playerJohnny Lowdermilk (born 1992), American football playerKirk Lowdermilk (born 1963), American football playerLou Lowdermilk (1887–1975), American baseball playerSusan Lowdermilk (born 1963), American artist and educatorWalter C. Lowdermilk (1888–1974), American soil conservationistWilliam Harrison Lowdermilk (1839–1897), American soldier