Louisville, Paducah and Southwestern Railroad

The Louisville, Paducah and Southwestern Railroad was a 19th-century railway company in western Kentucky in the United States. It operated from 1874, when it purchased the Elizabethtown and Paducah, until 1876, when it was purchased by the Paducah and Elizabethtown. It later made up part of the Illinois Central network and its former rights-of-way currently form parts of the class-II Paducah and Louisville Railway.

It connected with the Owensboro and Russellville Railroad and the later Evansville, Owensboro and Nashville Railroad (both subsequently part of the L&N network) at Central City in Muhlenberg County.