Louis is a surname. Notable people with the surname include:
Antoine Louis (1723–1792), French surgeon and physiologistArthur Louis (1945–2014), British musicianErrol Louis (born 1962), American journalist and television show hostChris Louis (born 1969), English speedway riderChristos Louis (born 1948), Greek molecular geneticistGodfrey Louis, solid-state physicistJean Louis (1907–1997), French-born costume designerJefferson Louis (born 1979), English footballerJoe Louis (1914–1981), American heavyweight boxerJulia Louis-Dreyfus (born 1961), American actress, comedian, and producerLance Louis (born 1985), American football playerLaurent Louis (born 1980), Belgian politicianLéopold Louis-Dreyfus (1833–1915), French businessman, founder of the Louis Dreyfus Group, and patriarch of the Louis-Dreyfus familyLil Louis, stage name of American house-music producer and DJ Louis SimsMichèle Pierre-Louis (born 1947), Haitian politicianMorris Louis (1912–1962), American painterMurray Louis (born 1926), American modern dancer and choreographerPierre Charles Alexandre Louis (1787–1872), French physicianSéraphine Louis (1864–1942), French painterSpyridon Louis (1873–1940), Greek runnerThomas Louis (1758–1807), British naval officerTim Louis (born 1958), Canadian lawyer and municipal politicianTristan Louis (born 1971), French-American authorWilliam Roger Louis (born 1936), American historian