Looney is a surname. Notable people with the surname include:
Andy Looney (born 1963), game designerJ. Thomas Looney (1870–1944), originator of the Oxfordian theory regarding the authorship of Shakespeare's playsJim Looney (born 1957), American football playerJoe Don Looney (1942–1988) American football playerJohn Patrick Looney (1867–1947), gangster in the Rock Island, Illinois area during the early 1900sJohn Looney (chief) (died 1838), chief of the Cherokee nationKevon Looney (born 1996), American basketball playerMichael O'Looney (born 1965) MD of Barclays USA, and former TV anchorWilliam R. Looney III (born 1949), former Commander, Air Education and Training Command, United States Air Force