Trade names Gleostine MedlinePlus a682207 Routes of
administration Oral (capsules) Molar mass 233.695 g/mol Protein binding 50% | AHFS/Drugs.com Monograph Pregnancy
category D ATC code L01AD02 (WHO) CAS ID 13010-47-4 | |
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Lomustine meaning
Lomustine (INN), abbreviated CCNU (original brand name (formerly available) is CeeNU, now marketed as Gleostine), is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, which is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).
Contents
- Lomustine meaning
- How to pronounce lomustine ceenu memorizing pharmacology video flashcard
- Rebranding
- References
Unlike carmustine, lomustine is administered orally. It is a monofunctional alkylating agent, alkylates both DNA and RNA, has the ability to cross-link DNA. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins. Lomustine is cell-cycle nonspecific.
How to pronounce lomustine ceenu memorizing pharmacology video flashcard
Rebranding
In 2014, the drug was re-launched and rebranded as Gleostine, manufactured by NextSource Biotechnology.