Supriya Ghosh (Editor)

Lomustine

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Trade names  Gleostine
MedlinePlus  a682207
Routes of administration  Oral (capsules)
Molar mass  233.695 g/mol
Protein binding  50%
AHFS/Drugs.com  Monograph
Pregnancy category  D
ATC code  L01AD02 (WHO)
CAS ID  13010-47-4
Lomustine

Lomustine meaning


Lomustine (INN), abbreviated CCNU (original brand name (formerly available) is CeeNU, now marketed as Gleostine), is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, which is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).

Contents

Unlike carmustine, lomustine is administered orally. It is a monofunctional alkylating agent, alkylates both DNA and RNA, has the ability to cross-link DNA. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins. Lomustine is cell-cycle nonspecific.

How to pronounce lomustine ceenu memorizing pharmacology video flashcard


Rebranding

In 2014, the drug was re-launched and rebranded as Gleostine, manufactured by NextSource Biotechnology.

References

Lomustine Wikipedia


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