This is a historical list, intended to deal with the time period where it's believed women working in science were rare. For this reason, this list ends with the 20th century.
Abrotelia (5th BCE), philosopher in Ancient Greece
Aemilia (c. 300 – 363), Gallo-Roman physician
Aesara of Lucania (4th or 3rd BCE), philosopher in Ancient Greece
Agamede (12th century BCE), (possibly mythical) physician in Ancient Greece
Aglaonike (2nd century BCE), the first woman astronomer in Ancient Greece
Agnodike (4th century BCE), the first woman physician to practice legally in Athens
Andromache (mid-6th century), Egyptian physician
Amyte (300 BCE), Greek physician and poet
Arete of Cyrene (5th–4th centuries BCE), natural and moral philosopher, North Africa
Artemisia of Caria (c. 300 BCE), botanist
Asclepigenia (4th AD), Greek Neoplatonist
Aspasia (4th century BCE), philosopher and scientist
Aspasia the Physician (fl. 1st century CE), Greek physician
Axiothea of Phlius (fl. c. 350 BCE), Greek philosopher
Beronice (1st AD), Roman philosopher
Caerellia (c. 45 BCE), Roman academician
Clea (1st-2nd century AD), philosopher
Cleachma (5th century BCE), Greek philosopher
Cleopatra the Alchemist - wrote the alchemical book, Chrysopoeia, or "gold-making".
Damo (6th century BCE), Greek natural philosopher
Diotima of Mantinea (4th century BCE), philosopher and scientist, ancient Greece (sources vary as to her historicity; possibly a fictionalized character based on Aspasia of Miletus)
Eccello of Lucania (5th or 4th century BCE), Greek/Italian mathematician and natural philosopher
Echecratia the Philiasian (5th century BCE), Greek/Italian mathematician and natural philosopher
Elephantis (1st century BCE), Greek physician
Enheduanna (c. 2285 – 2250 BCE), Sumerian/Akkadian astronomer and poet
Fabiola (died 399), Roman physician
Favilla (2nd century), Roman physician
Gargi Vachaknavi (7th century BCE), Indian philosopher
Hypatia (370–415), mathematician and astronomer, Egypt
Laïs, midwife
Lastheneia of Mantinea, (5th century BCE), student of Plato
Leontium (3rd BCE), Greek philosopher
Leoparda (4th century AD), gynecologist
Macrina (4th century AD), Greek physician and nun
Marcella (4th century AD), Roman healer
Mary the Jewess (1st or 2nd century CE), alchemist
Melissa (3rd century BCE), Greek philosopher
Merit Ptah (c. 2700 BCE), Egyptian physician
Metrodora (c. 200 – 400 AD), Greek physician and author
Myia (5th century BCE), Greek philosopher
Nicerata (c. 5th century), physician and healer
Occello of Lucania (4th or 5th century BCE), Greek natural philosopher and mathematician
Olympias of Thebes (1st century BCE), Greek midwife
Origenia (2nd century AD), Greek healer
Paphnutia the Virgin (c. 300), Egiptian alchemist
Paula (347–404 CE), Roman healer
Perictione (5th century BCE), Greek philosopher, mother of Plato
Peseshet Egyptian physician (Fourth Dynasty)
Pulcheria (5th century AD), healer
Pythias of Assos (4th century BCE), marine zoologist
Salpe (1st century BCE), Greek midwife
Sotira (1st century BCE), Greek physician
Tapputi-Belatekallim (First mentioned in a clay tablet dating to 2000 BCE), Babylonian perfumer, the first person in history recorded as using a chemical process.
Theano (6th century BCE), philosopher, mathematician and physician
Thelka, Iranian
Theosebeia (4th century AD), healer
List of female scientists before the 20th century Wikipedia (Text) CC BY-SA