Lightfoot is a surname. Notable people with the surname include:
Chris Lightfoot (footballer) (born 1970), former English footballerClaude Lightfoot (1910–1986), African-American activistDavid Lightfoot, Australian film producerEdwin N. Lightfoot, Emeritus Professor of Chemical Engineering at the University of Wisconsin–MadisonGenevievette Walker-Lightfoot, American former U.S. Securities and Exchange Commission attorneyGordon Lightfoot (born 1938), Canadian singer-songwriterHannah Lightfoot (1730–1759), sometimes erroneously named wife of George III of the United KingdomJim Ross Lightfoot (born 1938), former U.S. Representative from IowaJohn Lightfoot (1602–1675), English churchman and rabbinical scholarJohn Lightfoot (biologist) (1735-1788), English naturalistJoseph Lightfoot (1828-1889), English theologian, translator of the Apostolic Fathers, and Bishop of DurhamMaxwell Gordon Lightfoot (1886-1911), English painterOrlando Lightfoot (born 1974), former American professional basketball playerRona Lightfoot (born 1936), Scottish bagpipe playerRoss Lightfoot (born 1936), Liberal member of the Australian Senate