Lightfoot is a surname. Notable people with the surname include:
Chris Lightfoot (footballer) (born 1970), former English footballer
Claude Lightfoot (1910–1986), African-American activist
David Lightfoot, Australian film producer
Edwin N. Lightfoot, Emeritus Professor of Chemical Engineering at the University of Wisconsin–Madison
Genevievette Walker-Lightfoot, American former U.S. Securities and Exchange Commission attorney
Gordon Lightfoot (born 1938), Canadian singer-songwriter
Hannah Lightfoot (1730–1759), sometimes erroneously named wife of George III of the United Kingdom
Jim Ross Lightfoot (born 1938), former U.S. Representative from Iowa
John Lightfoot (1602–1675), English churchman and rabbinical scholar
John Lightfoot (biologist) (1735-1788), English naturalist
Joseph Lightfoot (1828-1889), English theologian, translator of the Apostolic Fathers, and Bishop of Durham
Maxwell Gordon Lightfoot (1886-1911), English painter
Orlando Lightfoot (born 1974), former American professional basketball player
Rona Lightfoot (born 1936), Scottish bagpipe player
Ross Lightfoot (born 1936), Liberal member of the Australian Senate
