Formula C23H22ClNO2 | Molar mass 379.879 g/mol | |
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Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis and which is under development by Merckle GmbH with partners Alfa Wassermann and Lacer.
Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. It has passed the phase III trials.
References
Licofelone Wikipedia(Text) CC BY-SA