Species Human Entrez 51520 | Human Mouse Ensembl ENSG00000133706 | |
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Aliases LARS, HSPC192, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl, ILFS1, Leucyl-tRNA synthetase External IDs MGI: 1913808 HomoloGene: 7083 GeneCards: LARS | ||
Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene.
Contents
Function
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.
Interactions
Leucyl-tRNA synthetase has been shown to interact with EEF1G.
References
Leucyl-tRNA synthetase Wikipedia(Text) CC BY-SA