EC number 2.4.99.11 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 55071-95-9 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a lactosylceramide alpha-2,6-N-sialyltransferase (EC 2.4.99.11) is an enzyme that catalyzes the chemical reaction
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramideThus, the two substrates of this enzyme are CMP-N-acetylneuraminate and beta-D-galactosyl-1,4-beta-D-glucosylceramide, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-, and glucosylceramide.
This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-lactosylceramide, sialyltransferase, CMP-acetylneuraminate-lactosylceramide-sialyltransferase, CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase, CMP-sialic acid:lactosylceramide sialyltransferase, cytidine monophosphoacetylneuraminate-lactosylceramide, and sialyltransferase.