Species Human Entrez 116844 | Human Mouse Ensembl ENSG00000171236 | |
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Aliases LRG1, HMFT1766, LRG, leucine-rich alpha-2-glycoprotein 1, leucine rich alpha-2-glycoprotein 1 External IDs MGI: 1924155 HomoloGene: 36468 GeneCards: LRG1 | ||
Gene music using protein sequence of lrg1 leucine rich alpha 2 glycoprotein 1
Leucine-rich alpha-2-glycoprotein 1 is a protein which in humans is encoded by the gene LRG1.
Contents
Function
The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation.
LRG1 has been shown to be involved in promoting neovascularization (new blood vessel growth) through causing a switch in transforming growth factor beta (TGFbeta) signaling in endothelial cells. LRG1 binds to the accessory receptor endoglin and promotes signaling via the ALK1-Smad1/5/8 pathway.
Application
Levels of the LRG protein are markedly elevated in acute appendicitis and therefore could be used as a diagnostic aid.
LRG1 may be a potential therapeutifc target for the treatment of diseases where there is aberrant neovascularization.