Aliases LPIN1, PAP1, lipin 1 Human Mouse Ensembl ENSG00000134324 | Species Human Entrez 23175 | |
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External IDs MGI: 1891340 HomoloGene: 9266 GeneCards: LPIN1 | ||
Lipin-1 is a protein that in humans is encoded by the LPIN1 gene.
Contents
Function
Lipin-1 has phosphatidate phosphatase activity. The nuclear localization of Lipin 1 is regulated by the mechanistic Target Of Rapamycin protein kinase and links mTORC1 activity to the regulation of Sterol regulatory element-binding proteins (SREBP)-dependent gene transcription.
Clinical significance
This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism.
References
LPIN1 Wikipedia(Text) CC BY-SA