Entrez 4005 | Ensembl ENSG00000135363 | |
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External IDs MGI: 102811 HomoloGene: 4072 GeneCards: LMO2 | ||
LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2. LMO2 is a protein which in humans is encoded by the LMO2 gene.
Contents
Function
LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.
Clinical significance
The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number of T-cell acute lymphoblastic leukemia-specific translocations occur.
Interactions
LMO2 has been shown to interact with:
References
LMO2 Wikipedia(Text) CC BY-SA