Species Human Entrez 8022 | Human Mouse Ensembl ENSG00000107187 | |
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Aliases LHX3, CPHD3, LIM3, M2-LIM homeobox 3 External IDs MGI: 102673 HomoloGene: 7814 GeneCards: LHX3 | ||
LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.
Contents
Function
LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.
Clinical significance
Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.
Interactions
LHX3 has been shown to interact with Ldb1.
References
LHX3 Wikipedia(Text) CC BY-SA