Species Human Entrez 7044 | Human Mouse Ensembl ENSG00000143768 | |
Aliases LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2 External IDs MGI: 2443573 HomoloGene: 2434 GeneCards: LEFTY2 | ||
Gene music using protein sequence of lefty2 left right determination factor 2
Left-right determination factor 2 is a protein that in humans is encoded by the LEFTY2 gene.
Contents
Function
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.