Species Human Entrez 3939 | Human Mouse Ensembl ENSG00000134333 | |
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Aliases LDHA, GSD11, HEL-S-133P, LDH1, LDHM, PIG19, lactate dehydrogenase A External IDs MGI: 96759 HomoloGene: 56495 GeneCards: LDHA | ||
Lactate dehydrogenase A, also known as LDHA, is an enzyme which in humans is encoded by the LDHA gene.
Contents
Function
Lactate dehydrogenase A catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
Model organisms
Model organisms have been used in the study of LDHA function. A conditional knockout mouse line, called Ldhatm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on mutant mice and five significant abnormalities were observed. Few homozygous mutant embryos were identified during gestation, and none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice. Animals of both sex had abnormal plasma chemistry, males also had improved glucose tolerance and increased red blood cell distribution width.
LDHA
The following compounds have been demonstrated to inhibit the LDHA enzyme: