EC number 2.6.1.36 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9054-68-6 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a L-lysine 6-transaminase (EC 2.6.1.36) is an enzyme that catalyzes the chemical reaction
Contents
L-lysine + 2-oxoglutarateThus, the two substrates of this enzyme are L-lysine and 2-oxoglutarate, whereas its two products are 2-aminoadipate 6-semialdehyde and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. This enzyme participates in lysine biosynthesis. It employs one cofactor, pyridoxal phosphate.
Nomenclature
The systematic name of this enzyme class is L-lysine:2-oxoglutarate 6-aminotransferase. Other names in common use include
Structure
L-lysine 6-transaminase belongs to the aminotransferase class-III family. Crystal structures of L-lysine 6-transaminase reveal a Glu243 “switch” through which the enzyme changes substrate specificities.