L aminoadipate semialdehyde dehydrogenase

Updated on Nov 07, 2023

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EC number 1.2.1.31 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 9067-87-2 BRENDA BRENDA entry KEGG KEGG entry

In enzymology, a L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) is an enzyme that catalyzes the chemical reaction

L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H₂O ⇌ L-2-aminoadipate + NAD(P)H + H⁺

The 4 substrates of this enzyme are L-2-aminoadipate 6-semialdehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are L-2-aminoadipate, NADH, NADPH, and H⁺.

This enzyme participates in lysine biosynthesis and biodegradation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include:

aminoadipate semialdehyde dehydrogenase,

2-aminoadipate semialdehyde dehydrogenase,

alpha-aminoadipate-semialdehyde dehydrogenase,

alpha-aminoadipate reductase,

2-aminoadipic semialdehyde dehydrogenase,

L-alpha-aminoadipate delta-semialdehyde oxidoreductase,

L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase,

L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine,

and dinucleotide oxidoreductase.

References

L-aminoadipate-semialdehyde dehydrogenase Wikipedia

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