Nationality American Name Krishna Kumar Role Chemist | ||
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Alma mater St. Stephen's College, DelhiBrown UniversityThe Scripps Research Institute Thesis Through Solvent Electron Transfer in Molecular C-Clamps (1996) Fields | ||
Doctoral advisor Matthew B. Zimmt Other academic advisors M. Reza Ghadiri Residence United States of America | ||
Ineterview with padmashree pr krishna kumar managing director of arya vaidya pharmacy
Krishna Kumar (born November 1, 1970) is an Indian American chemist whose research spans organic chemistry, chemical biology, bioorganic chemistry, biophysics and cell biology. He is currently Professor and Chair of Chemistry and was also Chemistry Department Chair from 2006 until 2009 at Tufts University.
Contents
- Ineterview with padmashree pr krishna kumar managing director of arya vaidya pharmacy
- Career
- Awards honors affiliations and positions
- Publications
- References
Career
Prior to Tufts University, he was at the Scripps Research Institute in La Jolla, California and got his bachelor's degree in Chemistry with honors from St. Stephen's College, Delhi and a Ph.D. degree in Chemistry (1996) from Brown University.
Kumar has given proteins hyperstable folding properties by inserting fluorinated amino acids into them. Recent studies by his research team have shown that fluorination of biologically active antimicrobial peptides is an effective strategy for improving their stability and antimicrobial therapeutic value.
In addition to antibiotics, Kumar's work includes the design of fluorinated drug delivery systems using lipids as carriers, and potential cancer drugs and imaging agents. His laboratory has also invented methods for cell surface engineering and imaging of cancer cells with metastatic potential.
Awards, honors, affiliations and positions
Publications
Web of Science shows these as the 10 most cited publications:
- Bilgiçer, B.; Fichera, A.; Kumar, K. "A Coiled Coil with a Fluorous Core."J. Am. Chem. Soc. 2001, 123, 4393-4399. Discussed by : "Fluorous Peptides." by Stu Borman, C&EN 2001, 79(20), 41-42; "Heart Cut" Chemical Innovation 2001, 31 (11), pp. 10. ; "Steps Towards Nanotechnology" by Jeffrey Soreff, Institute for Molecular Manufacturing (IMM), IMM Report No. 26, October 23, 2001.
- Bilgiçer, B.; Xing, X.; Kumar, K. "Programmed Self-Sorting of Coiled Coils with Leucine and Hexafluoroleucine Cores." J. Am. Chem. Soc. 2001, 123, 11815-11816. Discussed by: Science & Technology Roundup, C&EN 2001, 79 (49), p. 35.
- Yoder, N. C.; Kumar, K. "Fluorinated Amino Acids in Protein Design and Engineering." Chem. Soc. Rev. 2002, 31, 335-341.
- Bilgicer B, Kumar K "Synthesis and thermodynamic characterization of self-sorting coiled coils " Tetrahedron 2002 58( 20) 4105-4112.
- Bilgiçer, B.; Kumar, K. "De Novo Design of Defined Helical Bundles in Membrane Environments." Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 15324-15329.
- Myers, K. E.; Kumar, K. "Fluorophobic Acceleration of Diels-Alder Reactions." J. Am. Chem. Soc 2000, 122, 12025-12026.
- Xing, X.; Fichera, A.; Kumar, K. "A Novel Synthesis of Enantiomerically Pure 5,5,5,5',5',5'–Hexafluoroleucine." Org. Lett. 2001, 3, 1285-1286.
- Meng, H.; Kumar, K. "Antimicrobial Activity and Protease Stability of Peptides Containing Fluorinated Amino Acids" J. Am. Chem. Soc. 2007, 129, 15615-15622. Discussed by: "Fluorous Peptides Get Ready to Heal" by Stephen Ritter, C&EN 2007, 85 (37), pp. 36–37; "Putting the "F" in peptides" by Randall C Willis; Drug Discovery News 2007, December.
- Montanari V.; Kumar, K. "Just Add Water: A New Fluorous Capping Reagent for Facile Purification of Peptides Synthesized on the Solid Phase." J. Am. Chem. Soc. 2004, 126, 9528-9529.
- Wang P, Fichera A, Kumar K, et al. "Alternative translations of a single RNA message: An identity switch of (2S,3R)-4,4,4-trifluorovaline between valine and isoleucine codons " (2004)Angewandte Chemie International Ed. 43 (28) 3664-3666.