Kopf (German: head) is a surname. Notable people with the surname include:
David Kopf, professor emeritus at the University of MinnesotaHerb Kopf, American football coachHinrich Wilhelm Kopf (1893–1961), German politicianJakub Kopf (1915–1983), Polish basketball playerLarry Kopf (1890–1986), professional baseball playerRichard G. Kopf (born 1946), federal judge in the U.S. District Court for the District of NebraskaWally Kopf (1899–1979), German American professional baseball playerOpa-locka Airport, Florida (ICAO: KOPF)