Kopf (German: head) is a surname. Notable people with the surname include:
David Kopf, professor emeritus at the University of Minnesota
Herb Kopf, American football coach
Hinrich Wilhelm Kopf (1893–1961), German politician
Jakub Kopf (1915–1983), Polish basketball player
Larry Kopf (1890–1986), professional baseball player
Richard G. Kopf (born 1946), federal judge in the U.S. District Court for the District of Nebraska
Wally Kopf (1899–1979), German American professional baseball player
Opa-locka Airport, Florida (ICAO: KOPF)