Species Human Entrez 3759 | Human Mouse Ensembl ENSG00000123700 | |
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Aliases KCNJ2, ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3, potassium voltage-gated channel subfamily J member 2 External IDs OMIM: 600681 MGI: 104744 HomoloGene: 20249 GeneCards: KCNJ2 | ||
The Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene.
Contents
Clinical significance
A defect in this gene is associated with Andersen-Tawil syndrome.
A mutation in the KCNJ2 gene has also been shown to cause short QT syndrome.
In research
In neurogenetics, Kir2.1 is used in Drosophila research to inhibit neurons, as overexpression of this channel will hyperpolarize cells.
In optogenetics, a trafficking sequence from Kir2.1 has been added to halorhodopsin to improve its membrane localization. The resulting protein eNpHR3.0 is used in optogenetic research to inhibit neurons with light.
Interactions
Kir2.1 has been shown to interact with:
References
Kir2.1 Wikipedia(Text) CC BY-SA