Suvarna Garge (Editor)

Kininogen 1

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Species
  
Entrez
  
3827

Human
  
Ensembl
  
ENSG00000113889

Kininogen 1

Aliases
  
KNG1, BDK, BK, KNG, Kininogen 1

External IDs
  
MGI: 1097705 HomoloGene: 88343 GeneCards: KNG1

Gene music using protein sequence of kng1 kininogen 1


Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein that in humans is encoded by the KNG1 gene. Kininogen-1 is the precursor protein to high-molecular-weight kininogen (HMWK), low-molecular-weight kininogen (LMWK), and bradykinin.

Contents

Expression

The KNG1 gene uses alternative splicing to generate two different proteins: high-molecular-weight kininogen (HMWK) and low-molecular-weight kininogen (LMWK). HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin.

  • KNG1 gene → low-molecular-weight kininogen (LMWK) protein (contains 427 amino acids) or high-molecular-weight kininogen (HMWK) protein (644 amino acids)
  • HMWK protein → bradykinin peptide (9 amino acids)
  • Function

    HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation.

    Kininogen-1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.

    References

    Kininogen 1 Wikipedia


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