After studying music and drama at Jewel and Esk Valley College, Edinburgh, she co-formed the dance band Nexus in 1993. She then joined QFX, whose single Freedom 2 reached Number 21 in the UK charts.
She was spotted by Kenny MacDonald, manager of The Proclaimers, in 1997 McGregor participated in The Great British Song Contest, the UK selection for the Eurovision Song Contest, with the song "Yodel in the Canyon of Love". The song came second, behind Katrina and the Waves' "Love Shine a Light", which went on to win the competition that year. Polygram later signed McGregor to a solo deal, and released "Yodel in the Canyon of Love" as a single.
McGregor had appeared in a number of stage and television shows including the Channel 4 comedy The Book Group playing Kenny's love-interest Carol Ann, and the BBC1 Children's drama series Grange Hill.
In 2006, McGregor was a finalist in the third UK series of TV talent show The X Factor. McGregor was mentored on the show by Sharon Osbourne. She was eliminated in the third week of the live shows along with Dionne Mitchell.
McGregor appeared at sell-out summer shows in Blackpool in 2007 and performed for the National Lottery Live, before taking a break to concentrate on her song-writing. In 2008, she recorded and toured with singer-songwriter Jay Brown appearing on his album, "Take What You Need" and worked with producer and musician Calais Brown. McGregor also performed at the 2010 Edinburgh International Festival, singing in concert with classical Tenor, Martin Aelred. In 2011, McGregor was appointed Ambassador to UK charity, Action on Bladder Cancer (ABC).
McGregor was born in 1974 in Pumpherston, West Lothian, Scotland. Her grandfather was Bobby McKerracher, known as "the Scottish Bing Crosby". After her father died in a car crash when she was aged five, she was raised by her mother, who was also a singer.
Joining West Calder High School, McGregor showed promise as a gymnast until aged 13, when she fell out of a tree and broke her back. Thereafter she was a wheelchair user, but in six weeks she learned to walk again using crutches, earning a Child of Achievement Award.
McGregor lived in West Lothian near Edinburgh, with her property developer partner and their son Joshua. In 2007, McGregor helped to launch the WheelieChix-Chic clothing brand at London Fashion Week.
After two years of complaining of stomach pains, in September 2010 McGregor was diagnosed with bladder cancer. After undergoing three months of chemotherapy, she revealed her diagnosis in an interview with The Sun in April 2011. On 4 January 2012 it was announced by McGregor's management on her Facebook page that she had died earlier that day from the disease. 400 people attended her funeral.