Keene is a surname. Notable people with the surname include:
Alfred Keene (1873–1955), British Olympic fencerAlfred John Keene (1864–1930), British watercolour artistBarry Keene (born 1938), American politician (California)Sir Benjamin Keene (1697–1757), British diplomatBill Keene (1927–2000), American television and radio personalityBrian Keene (born 1967), American author, primarily of horror and crime fictionCarolyn Keene, pseudonym used 1930–85 by the authors of the Nancy Drew and the Dana Girls mystery storiesCharles Keene (disambiguation), multiple peopleChristopher Keene (1946–95), American classical music conductorConstance Keene (1921–2005), American classical pianistDaniel Keene (born 1955), Australian playwrightDavid Keene (born 1945), American former President of the National Rifle AssociationSir David Keene, a British Lord Justice of AppealDennis Keene (born 1965), American politician (Kentucky)Donald Keene (born 1922), American scholar, historian, teacher, writer and translator of JapaneseDoug Keene (1928–86), English footballerElodie Keene (born 1949), American film and television director, producer and editorEdmund Keene (1714–81), English churchman and academicFoxhall P. Keene (1867–1941), American owner and breeder of thoroughbred race horses, World and Olympic gold medallist at poloHenry Keene (1726–76), English architectHenry George Keene (1826–1915) (1826–1915), English historian of mediaeval and modern IndiaJames Keene (disambiguation), multiple peopleJasmine Keene (born 1987), Australian netball playerJean Keene ("The Eagle Lady", 1923–2009), American rodeo trick riderJohn Keene (disambiguation), multiple peopleJoseph Keene (1839–1921), American Medal of Honor recipientJudith Keene (active 1977–2008), Commandant of Cadets at the U.S. Coast Guard AcademyKaty Keene, strip cartoon character created by Bill Woggon in 1945M. Lamar Keene (1936–96), American spirit mediumLaura Keene (1826–73), British stage actor and managerLaurie Keene (born 1961), Australian rules footballerMarcus Keene (born 1995), American basketball playerMarion Keene (Marion Davis, active early 1950s–after 1998), British big-band vocalistMimi Keene (born 1998), British actressNelson Keene (born Malcolm Holland, 1942), British pop singerNietzchka Keene (1952–2004), American film director and writerPaul K. Keene (1910–2005), American organic farming pioneerPercival Keene, coming-of-age adventure novel published in three volumes in 1842 by Frederick MarryatRaymond Keene (born 1948), English chess GrandmasterRichard Keene (1825–94), British photographerRick Keene (Richard J. "Rick" Keene, born 1957), American politician (California)Spec Keene (Roy S. "Spec" Keene, 1894–1977), American college sports coachSteve Keene (born 1957), American artistTom Keene (disambiguation), multiple peopleTommy Keene (born 1958), American singer-songwriterWilliam Keene (1915–1992), American television actor