Keene is a surname. Notable people with the surname include:
Alfred Keene (1873–1955), British Olympic fencer
Alfred John Keene (1864–1930), British watercolour artist
Barry Keene (born 1938), American politician (California)
Sir Benjamin Keene (1697–1757), British diplomat
Bill Keene (1927–2000), American television and radio personality
Brian Keene (born 1967), American author, primarily of horror and crime fiction
Carolyn Keene, pseudonym used 1930–85 by the authors of the Nancy Drew and the Dana Girls mystery stories
Charles Keene (disambiguation), multiple people
Christopher Keene (1946–95), American classical music conductor
Constance Keene (1921–2005), American classical pianist
Daniel Keene (born 1955), Australian playwright
David Keene (born 1945), American former President of the National Rifle Association
Sir David Keene, a British Lord Justice of Appeal
Dennis Keene (born 1965), American politician (Kentucky)
Donald Keene (born 1922), American scholar, historian, teacher, writer and translator of Japanese
Doug Keene (1928–86), English footballer
Elodie Keene (born 1949), American film and television director, producer and editor
Edmund Keene (1714–81), English churchman and academic
Foxhall P. Keene (1867–1941), American owner and breeder of thoroughbred race horses, World and Olympic gold medallist at polo
Henry Keene (1726–76), English architect
Henry George Keene (1826–1915) (1826–1915), English historian of mediaeval and modern India
James Keene (disambiguation), multiple people
Jasmine Keene (born 1987), Australian netball player
Jean Keene ("The Eagle Lady", 1923–2009), American rodeo trick rider
John Keene (disambiguation), multiple people
Joseph Keene (1839–1921), American Medal of Honor recipient
Judith Keene (active 1977–2008), Commandant of Cadets at the U.S. Coast Guard Academy
Katy Keene, strip cartoon character created by Bill Woggon in 1945
M. Lamar Keene (1936–96), American spirit medium
Laura Keene (1826–73), British stage actor and manager
Laurie Keene (born 1961), Australian rules footballer
Marcus Keene (born 1995), American basketball player
Marion Keene (Marion Davis, active early 1950s–after 1998), British big-band vocalist
Mimi Keene (born 1998), British actress
Nelson Keene (born Malcolm Holland, 1942), British pop singer
Nietzchka Keene (1952–2004), American film director and writer
Paul K. Keene (1910–2005), American organic farming pioneer
Percival Keene, coming-of-age adventure novel published in three volumes in 1842 by Frederick Marryat
Raymond Keene (born 1948), English chess Grandmaster
Richard Keene (1825–94), British photographer
Rick Keene (Richard J. "Rick" Keene, born 1957), American politician (California)
Spec Keene (Roy S. "Spec" Keene, 1894–1977), American college sports coach
Steve Keene (born 1957), American artist
Tom Keene (disambiguation), multiple people
Tommy Keene (born 1958), American singer-songwriter
William Keene (1915–1992), American television actor
