The film stars Isabelle Cyr as Karmina, a vampire from Transylvania who runs away to live with her aunt Esméralda (France Castel) in Quebec to escape an arranged marriage to Vlad (Yves Pelletier). Vampires living in North America have access to a magic potion which enables them to keep their vampire natures in check so that they can live in harmony with humans, and Karmina begins a relationship with Philippe (Robert Brouillette), a church organist. However, Vlad and Karmina's parents (Raymond Cloutier and Sylvie Potvin) soon show up to retrieve her.
A sequel film, Karmina 2: L'Enfer de Chabot, was released in 2001.
The film won two Genie Awards at the 18th Genie Awards, for Best Art Direction/Production Design and Best Costume Design, as well as a special award for Best Make-Up (which is not a regular Genie Award category.) It was also nominated, but did not win, in the categories of Best Picture, Best Actress (Isabelle Cyr), Best Supporting Actress (France Castel), Best Director (Gabriel Pelletier), Best Screenplay, Best Cinematography, Best Editing (Gaétan Huot), Best Overall Sound (Jo Caron) and Best Sound Editing.