Kain is a surname. Notable people with the surname include:
Andy Kain, rugby league playerBob Kain, businessmanConrad Kain (1883–1934), guideEdgar James "Cobber" Kain (1918–1940), pilotGabriella Kain (born 1981), Swedish handball goalkeeperGylan Kain, poet/playwrightJohn Kain, rugby league playerJohn Joseph Kain, ArchbishopKaren Kain (born 1951), Canadian dancerKevin Kain, Canadian doctorKhalil Kain (born 1964), actorLekain (1728–1778), actorSaul Kain, moniker ofShauna Kain, actressSophie Kain, research scientist on the ApprenticeStuart Kain, rugby league player for Featherstone RoversTom Kain (born 1963), businessmanTyler Kain (born 1982), actress