Kain is a surname. Notable people with the surname include:
Andy Kain, rugby league player
Bob Kain, businessman
Conrad Kain (1883–1934), guide
Edgar James "Cobber" Kain (1918–1940), pilot
Gabriella Kain (born 1981), Swedish handball goalkeeper
Gylan Kain, poet/playwright
John Kain, rugby league player
John Joseph Kain, Archbishop
Karen Kain (born 1951), Canadian dancer
Kevin Kain, Canadian doctor
Khalil Kain (born 1964), actor
Lekain (1728–1778), actor
Saul Kain, moniker of
Shauna Kain, actress
Sophie Kain, research scientist on the Apprentice
Stuart Kain, rugby league player for Featherstone Rovers
Tom Kain (born 1963), businessman
Tyler Kain (born 1982), actress
