Species Human Entrez 3881 | Human Mouse Ensembl n/a | |
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Aliases KRT31, HA1, Ha-1, KRTHA1, hHa1, keratin 31 External IDs MGI: 1309993 HomoloGene: 74433 GeneCards: KRT31 | ||
Keratin, type I cuticular Ha1 is a protein that in humans is encoded by the KRT31 gene.
Contents
Function
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.
Model organisms
Model organisms have been used in the study of KRT31 function. A conditional knockout mouse line called Krt31tm1e(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping
References
KRT31 Wikipedia(Text) CC BY-SA