Species Human Entrez 3840 | Human Mouse Ensembl ENSG00000186432 | |
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Aliases KPNA4, IPOA3, QIP1, SRP3, karyopherin subunit alpha 4 External IDs MGI: 1100848 HomoloGene: 20521 GeneCards: KPNA4 | ||
Importin subunit alpha-4 is a protein that in humans is encoded by the KPNA4 gene.
Contents
Function
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
Interactions
KPNA4 has been shown to interact with RECQL and STAT3.
References
KPNA4 Wikipedia(Text) CC BY-SA