Species Human Entrez 3818 | Human Mouse Ensembl ENSG00000164344 | |
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Aliases KLKB1, KLK3, PPK, PKKD, PKK, kallikrein B1 External IDs MGI: 102849 HomoloGene: 68097 GeneCards: KLKB1 | ||
Gene music using protein sequence of klkb1 kallikrein b plasma fletcher factor 1
Plasma kallikrein is a protein that in humans is encoded by the KLKB1 gene.
Contents
Function
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
Interactions
KLKB1 has been shown to interact with High-molecular-weight kininogen.