Species Human Entrez 9371 | Human Mouse Ensembl ENSG00000101350 | |
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Aliases KIF3B, FLA8, HH0048, KLP-11, kinesin family member 3B External IDs MGI: 107688 HomoloGene: 55849 GeneCards: KIF3B | ||
Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene.
Contents
Function
The protein encoded by this gene forms a heterotrimeric motor complex with kinesin family member 3A and KAP3 (kinesin accessory protein 3) to drive intra-flagellar transport and possibly to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. The heterotrimeric KIF3B/KIF3A/KAP3 motor protein is a member of the kinesin-2 subfamily of the kinesin superfamily.
Interactions
KIF3B has been shown to interact with RAB4A.
Model organisms
Model organisms have been used in the study of KIF3B function. A conditional knockout mouse line called Kif3btm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping