Species Human Entrez 3762 | Human Mouse Ensembl ENSG00000120457 | |
Aliases KCNJ5, CIR, GIRK4, KATP1, KIR3.4, LQT13, potassium voltage-gated channel subfamily J member 5 External IDs MGI: 104755 HomoloGene: 20248 GeneCards: KCNJ5 | ||
G protein-activated inward rectifier potassium channel 4 is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein-gated ion channel.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with other G-protein-activated potassium channel subunits to form a heterotetrameric pore-forming complex.
Mutations in KCNJ5/Kir3.4 cause Andersen-Tawil syndrome .
Interactions
KCNJ5 has been shown to interact with KCNJ3.