Neha Patil (Editor)

KCNAB2

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Species
  
Human

Entrez
  
8514

Human
  
Mouse

Ensembl
  
ENSG00000069424

KCNAB2

Aliases
  
KCNAB2, AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2, potassium voltage-gated channel subfamily A regulatory beta subunit 2

External IDs
  
MGI: 109239 HomoloGene: 56492 GeneCards: KCNAB2

Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.

Contents

Function

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

In melanocytic cells KCNAB2 gene expression may be regulated by MITF.

Interactions

KCNAB2 has been shown to interact with KCNA2.

References

KCNAB2 Wikipedia