Entrez 8514 | Ensembl ENSG00000069424 | |
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Aliases KCNAB2, AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2, potassium voltage-gated channel subfamily A regulatory beta subunit 2 External IDs MGI: 109239 HomoloGene: 56492 GeneCards: KCNAB2 | ||
Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.
Contents
Function
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
In melanocytic cells KCNAB2 gene expression may be regulated by MITF.
Interactions
KCNAB2 has been shown to interact with KCNA2.