Blue was born in Cameroon where his father, Walter Blue, was a professor of Romance languages at Hamline University teaching during a mission. Blue grew up in Saint Paul, Minnesota and graduated from Como Park Senior High School in 1997. He began his career as a comedian while seeking a creative writing degree at The Evergreen State College.
During college, he went back to Africa to volunteer as an intern at Parc de Hahn, a zoo in Senegal. At one point for a joke on a busy weekend, Josh locked himself in an empty animal exhibit for 8 hours. A bewildered crowd threw him bananas and peanuts anyway, to which Josh quips "that was the best day I ate in Senegal!"
Blue got his start in comedy doing open mic sets while attending The Evergreen State College. Audiences reacted enthusiastically to his self-deprecating humor, and Blue started making a name for himself on the comedy circuit. In 2002, he won the prestigious Comedy Works New Talent Search contest. He has appeared several times on Comedy Central's Mind of Mencia. Blue won $10,000 for finishing in first place at 2004 Las Vegas Comedy Festival's 2004 Royal Flush Comedy Competition.
After winning the 2006 season of NBC's reality show Last Comic Standing, he was the first comedian to do stand-up on The Ellen DeGeneres Show. His other television credits include Live with Regis and Kelly, Comics Unleashed, plus numerous appearances on Fox, CBS, ABC, and MSNBC.
He appeared in the 2009 low-budget horror film Feast III: The Happy Finish.
Josh was voted the 13th best comedian by viewers in Comedy Central's Stand-up Comedy Showdown 2010.
Blue appeared in Boulder band Rose Hill Drive's music video "The Psychoanalyst".
Blue was voted the 11th best comedian by viewers in Comedy Central's Stand-up Comedy Showdown 2011.
He appeared in Ron White's Las Vegas Salute to the Troops 2013 as part of the opening act.
Blue also appeared in the sports based comedy 108 Stitches in 2014.
Blue currently resides in Denver, Colorado with his two children - a son, Simon, and a daughter, Seika.
Blue played a part in the 2004 U.S. Paralympic soccer team. He also creates and sells sculptures and paintings. One particular piece he sells at an extremely high price, because, as he said on his appearance on The Ellen DeGeneres Show, "I nearly died making it."
Blue has cerebral palsy , specifically classified as spastic hemiplegia cerebral palsy, and many of his jokes center on living with his disability, how he deals with it, and how other people view him. Blue appeared on Last Comic Standing to "make people aware of the fact that people with disabilities can make an impact." He coined the term "palsy punch" during his final set of the final round of the show, when he said that the palsy punch is effective in a fight because "first of all, they don't know where the punch is coming from, and second of all, neither do I." One of Blue's competitors said he has "an unreasonable amount of likability" while another of his competitors said "he is just a good guy". Blue also joked that signing an autograph takes 45 minutes, and that to write down his phone number he has to find a "big ol' stack of paper."Good Josh, Bad Arm (2008)
Hooligan Stew (2012)
Sticky Change (2013)