Josephson is a patronymic surname meaning "son of Joseph". Notable people with the surname include:
Andy Josephson (born 1964), American lawyer and politicianBrian David Josephson (born 1940), Welsh physicistDuane Josephson (1942–1997), American baseball playerErland Josephson (1923–2012), Swedish actor and authorErnst Josephson (1851–1906), Swedish painterIan Josephson, Canadian judgeJulien Josephson (1881–1959), American motion picture screenwriterKaren Josephson (born 1964), American swimmerLes Josephson (born 1942), American football playerMark Josephson (born 1943), American cardiac electrophysiologistMatthew Josephson (1899–1978), American journalist and authorSarah Josephson (born 1964), American swimmer