Residence US Fields Biology Nationality American | Name Joseph DeRisi Awards MacArthur Fellowship Role Molecular Biologist | |
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Institutions University of California, San Francisco Howard Hughes Medical Institute Alma mater Stanford University, University of California, Santa Cruz Known for ViroChip, work on identifying SARS virus, gene expression in Plasmodium falciparum Notable awards 2001 Searle Scholar Award, The Searle Scholars Program, Northbrook IL
2001 JP Morgan Chase Health Award, The Tech Museum of Innovation, San Jose CA
2002 Gordon Tomkins Chair of Biochemistry and Biophysics, University of California, San Francisco
2003 Packard Fellowship for Science and Engineering, David and Lucile Packard Foundation, Los Altos, CA
2004 MacArthur Fellowship, The John D. and Catherine T. MacArthur Foundation, Chicago, IL
2004 Wired RAVE Award, Health and Medicine, WIRED Magazine, San Francisco, CA
2005 BayBio Scientific Achievement Award, BayBio, San Francisco, CA
2006 Alumni Achievement Award, University of California, Santa Cruz, Santa Cruz, CA
2007 Chabot Science Award, Chabot Space & Science Center, Oakland, CA
2008 The 14th Heinz Award for Technology, the Economy and Employment, Heinz Foundations, Pittsburgh, PA Education University of California, Santa Cruz, Stanford University | ||
Doctoral advisor Patrick O. Brown | ||
Genome Sequencing for Pathogen Discovery - Joseph DeRisi (UCSF, HHMI)
Joseph DeRisi is an American biochemist, specializing in molecular biology, parasitology, genomics, virology, and computational biology.
Contents
- Genome Sequencing for Pathogen Discovery Joseph DeRisi UCSF HHMI
- Joseph derisi ucsf part 1 malaria the disease and parasites
- Life
- Awards
- References
Joseph derisi ucsf part 1 malaria the disease and parasites
Life
He received a B.A. in Biochemistry and Molecular Biology (1992) from the University of California, Santa Cruz, and a Ph.D. in Biochemistry (1999) from Stanford University.
Joseph DeRisi is currently a Howard Hughes Medical Institute (HHMI) Investigator and a Professor and Chairman of the Department of Biochemistry and Biophysics at the University of California, San Francisco (UCSF) with a joint appointment at the California Institute for Quantitative Biosciences (QB3).
DeRisi's best-known achievements are printing the first whole genome expression array (Derisi et al., 1997, Science; PMID 9381177), performing the first broad analysis of differential gene expression in cancer cells (Derisi et al., 1996, Nature Genetics; PMID 8944026), profiling gene expression throughout the lifecycle of the malaria-causing protozoan Plasmodium falciparum, his discovery of the SARS virus, and pioneering virus discovery using gene hybridization array and DNA sequencing technologies (Wang et al., 2002, PNAS, PMID 12429852). Joe is also known for tackling any "cool problem" whatsoever, which generally come in the form of biological questions complicated by obstacles not surmountable without invention of new protocols and techniques.
DeRisi uses microarrays extensively in his work, and has designed and built both hardware and software for microarrays. He is a proponent of open access to microarray technology, and maintains a website with software and protocols for microarray operations. He is also a proponent of open access publishing, and has publications in the Public Library of Science journals.
DeRisi has identified putative disease-causing viruses in humans (cancer, SARS, other respiratory infections, etc.), and animals ranging from parrots and cockatiels to honeybees and boa constrictors. He and a research partner, Don Ganem, have identified a parasite, Nosema ceranae, that appears to be responsible for colony collapse among honeybees. http://today.ucsf.edu/stories/ucsf-sleuths-identify-suspects-in-mystery-of-vanishing-honeybees/. He has also de-bunked the relation of viruses to certain subsets of human cancer.
Perhaps most relevant to contemporary global health, based on extensive characterization of the malaria-causing pathogen, Plasmodium falciparum, DeRisi's group has developed profoundly promising candidate drugs to cure malaria and a model for a vaccine to prevent malaria.
In 2004 DeRisi was named a MacArthur fellow (the "Genius" award), in 2008 was awarded the 14th Annual Heinz Award for Technology, the Economy, and Employment, and in 2014 he received the John J. Carty Award for the Advancement of Science from the National Academy of Sciences. In 2016 he was elected to the National Academy of Sciences.