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John Kendrew

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Nationality
  
United Kingdom

Role
  
Crystallographer

Name
  
John Kendrew


Doctoral advisor
  
Max Perutz

Institutions
  
Royal Air Force

Fields
  
Crystallography

John Kendrew Obituary John Cowdery Kendrew 191797 Article Nature

Born
  
24 March 1917 Oxford, England (
1917-03-24
)

Alma mater
  
University of Cambridge

Known for
  
Heme-containing proteins

Notable awards
  
Nobel Prize for Chemistry (1962) Royal Medal (1965)

Died
  
August 23, 1997, Cambridge

Awards
  
Nobel Prize in Chemistry, Royal Medal, William Procter Prize for Scientific Achievement

Books
  
The Thread of Life: An Introduction to Molecular Biology

Education
  
University of Cambridge, Trinity College, Cambridge

Similar People
  
Max Perutz, John Desmond Bernal, Francis Crick, James Watson, Hugh Huxley

3 of 8 john kendrew protein crystallography in the cavendish laboratory in the 1950 s


Sir John Cowdery Kendrew, CBE, FRS (24 March 1917 – 23 August 1997) was an English biochemist and crystallographer who shared the 1962 Nobel Prize in Chemistry with Max Perutz; their group in the Cavendish Laboratory investigated the structure of heme-containing proteins.

Contents

John Kendrew John C Kendrew September 1953 Large Version

Education and early life

John Kendrew wwwnndbcompeople551000100251johnckendrew1

He was born in Oxford, son of Wilford George Kendrew, reader in climatology in the University of Oxford, and Evelyn May Graham Sandburg, art historian. After prep school at the Dragon School in Oxford, he was educated at Clifton College in Bristol, 1930–1936. He attended Trinity College, Cambridge in 1936, as a Major Scholar, graduating in chemistry in 1939. He spent the early months of World War II doing research on reaction kinetics, and then became a member of the Air Ministry Research Establishment, working on radar. In 1940 he became engaged in operational research at the Royal Air Force headquarters, holding the honorary rank of Wing Commander R.A.F.

Research and career

John Kendrew Kendrew Sir John Cowdery Lexikon der Biologie

During the war years, he became increasingly interested in biochemical problems, and decided to work on the structure of proteins.

Crystallography

John Kendrew John Kendrew Wikipedia

In 1945 he approached Max Perutz in the Cavendish Laboratory in Cambridge. Joseph Barcroft, a respiratory physiologist, suggested he might make a comparative protein crystallographic study of adult and fetal sheep hemoglobin, and he started that work.

John Kendrew John Kendrew Biography Childhood Life Achievements Timeline

In 1947 he became a Fellow of Peterhouse; and the Medical Research Council (MRC) agreed to create a research unit for the study of the molecular structure of biological systems, under the direction of Sir Lawrence Bragg. In 1954 he became a Reader at the Davy-Faraday Laboratory of the Royal Institution in London.

Crystal structure of myoglobin

John Kendrew 3 of 8 John Kendrew Protein Crystallography in the Cavendish

Kendrew shared the 1962 Nobel Prize for chemistry with Max Perutz for determining the first atomic structures of proteins using X-ray crystallography. Their work was done at what is now the MRC Laboratory of Molecular Biology in Cambridge. Kendrew determined the structure of the protein myoglobin, which stores oxygen in muscle cells. On Saturday 20 October 1962 the award of Nobel prizes to John Kendrew and Max Perutz, and to Crick, Watson, and Wilkins was satirised in a short sketch in the BBC TV programme That Was The Week That Was with the Nobel Prizes being referred to as 'The Alfred Nobel Peace Pools'.

John Kendrew Video John Kendrew 1964 Recent Studies of the Structure of

In 1947 the MRC agreed to make a research unit for the Study of the Molecular Structure of Biological Systems. The original studies were on the structure of sheep hemoglobin, but when this work had progressed as far as was possible using the resources then available, Kendrew embarked on the study of myoglobin, a molecule only a quarter the size of the hemoglobin molecule. His initial source of raw material was horse heart, but the crystals thus obtained were too small for X-ray analysis. Kendrew realized that the oxygen-conserving tissue of diving mammals could offer a better prospect, and a chance encounter led to his acquiring a large chunk of whale meat from Peru. Whale myoglobin did give large crystals with clean X-ray diffraction patterns. However, the problem still remained insurmountable, until in 1953 Max Perutz discovered that the phase problem in analysis of the diffraction patterns could be solved by multiple isomorphous replacement — comparison of patterns from several crystals; one from the native protein, and others that had been soaked in solutions of heavy metals and had metal ions introduced in different well-defined positions. An electron density map at 6 angstrom (0.6 nanometre) resolution was obtained by 1957, and by 1959 an atomic model could be built at 2 angstrom (0.2 nm) resolution.

Later career

In 1963 Kendrew became one of the founders of the European Molecular Biology Organization; as well, he founded and was for many years editor-in-chief of the Journal of Molecular Biology. He became Fellow of the American Society of Biological Chemists in 1967 and honorary member of the International Academy of Science. In 1974 he succeeded in persuading governments to establish the European Molecular Biology Laboratory in Heidelberg and became its first director. From 1974 to 1979 he was a Trustee of the British Museum, and from 1974 to 1988 he was successively Secretary General, Vice-President, and President of the International Council of Scientific Unions.

After his retirement from the European Molecular Biology Laboratory, Kendrew became President of St John's College at Oxford University, a post he held from 1981 to 1987. Kendrew's entry in Who's Who lists ten other important national and international committees on which he served as either member or chairman.

The Kendrew Quadrangle at St John's College in Oxford, officially opened on 16 October 2010, is named after him.

His scientific biography is currently being written by Paul Wasserman.

References

John Kendrew Wikipedia