Jesse Sene-Lefao (born 8 December 1989) is a New Zealand professional rugby league footballer who currently plays for the Castleford Tigers in the Super League in England. He plays at second-row and prop, and previously played for the Manly Warringah Sea Eagles.
Sene-Lefao is nephew of West Tigers centre Tim Simona and cousin of North Queensland Cowboys centre Matthew Wright. Sene-Lefao is of Samoan descent.
Sene-Lefao played his junior football for the Penrith Brothers before being signed by the Penrith Panthers. Sene-Lefao played for the Panthers' NYC team in 2008 and 2009, scoring 15 tries in 38 games.
In 2013, Sene-Lefao joined the Manly-Warringah Sea Eagles. He made his NRL debut in the opening round of the season against the Brisbane Broncos at Suncorp Stadium, playing off the interchange bench in the Sea Eagles 22-14 win. Sene-Lefao played his 2nd and last match for the year in round 8. He spent most the year playing for the team's New South Wales Cup team.
Sene-Lefao was selected in the Sea Eagles inaugural 2014 NRL Auckland Nines squad. He made his international debut in May for Samoa in the test against Fiji at Penrith Stadium. Sene-Lefao played off the interchange bench in Samoa's 32-16 win. Soon after, Sene-Lefao re-signed with the Sea Eagles on a 2-year contract.
In Round 13 against the Canterbury-Bankstown Bulldogs at Brookvale Oval, Sene-Lefao scored his first NRL career try in the Sea Eagles 32-10 win. It was the sole try he scored from 25 matches in 2014. At the end of the season, Sene-Lefao was a late selection for Samoa in the Four Nations after Suaia Matagi was selected in the New Zealand Kiwis squad.
Sene-Lefao was again part of the Sea Eagles Auckland Nines squad in 2015. He scored 2 tries from his 11 matches in 2015. On 9 October, Sene-Lefao signed a 2-year contract with the Cronulla-Sutherland Sharks, starting from 2016 after he was released from his final year of his contract with Manly.
Sene-Lefao played 6 games for the Cronulla Sutherland Sharks in 2016, he did not play in Cronulla's 2016 drought breaking premiership win.
On the 21st of October, 2016, Sene-Lefao signed a two year contract that will see him be at the Castleford Tigers until 2018.