Jernigan is a surname. Notable people with the surname include:
Aaron Jernigan (1813–1891), early U.S. settler
Dennis Jernigan (born 1959), U.S. Christian singer-songwriter
Doug Jernigan (born 1946), U.S. musician
Gerald D. Jernigan (1942–2006), U.S. politician
Harry Jernigan, fictional character from The Towering Inferno
Jerrel Jernigan (born 1989), American Football Player
Joseph Paul Jernigan (1954–1993), U.S. murderer
Kenneth Jernigan (1926–1998), blind U.S. civil rights activist
Kenton Jernigan, U.S. squash player
Tamara E. Jernigan (born 1959), U.S. scientist and astronaut
Thomas R. Jernigan, US Senator, and Consul-General in Shanghai
