Jernigan is a surname. Notable people with the surname include:
Aaron Jernigan (1813–1891), early U.S. settlerDennis Jernigan (born 1959), U.S. Christian singer-songwriterDoug Jernigan (born 1946), U.S. musicianGerald D. Jernigan (1942–2006), U.S. politicianHarry Jernigan, fictional character from The Towering InfernoJerrel Jernigan (born 1989), American Football PlayerJoseph Paul Jernigan (1954–1993), U.S. murdererKenneth Jernigan (1926–1998), blind U.S. civil rights activistKenton Jernigan, U.S. squash playerTamara E. Jernigan (born 1959), U.S. scientist and astronautThomas R. Jernigan, US Senator, and Consul-General in Shanghai