Jefferies is a surname. Notable people with the surname include:
Alan Jefferies (born 1957), Australian writer
Chris Jefferies (born 1980), American basketball player
Cindy Jefferies, English writer of fiction for children
Darren Jefferies (born 1993), English footballer
Dinah Jefferies (born 1948), English writer
Gregg Jefferies (born 1967), American baseball infielder
Jim Jefferies (disambiguation), multiple people, including:
Jim Jefferies (footballer) (born 1950), Scottish football player and manager
Jim Jefferies (comedian) (born 1977), Australian comedian
Matt Jefferies (1921–2003), American artist, set designer and writer
Richard Jefferies (1848–1887), English nature writer
Thomas Jeffries, also known as Thomas Jefferies (died 1826), Australian outlaw & prisoner
