Jefferies is a surname. Notable people with the surname include:
Alan Jefferies (born 1957), Australian writerChris Jefferies (born 1980), American basketball playerCindy Jefferies, English writer of fiction for childrenDarren Jefferies (born 1993), English footballerDinah Jefferies (born 1948), English writerGregg Jefferies (born 1967), American baseball infielderJim Jefferies (disambiguation), multiple people, including:Jim Jefferies (footballer) (born 1950), Scottish football player and managerJim Jefferies (comedian) (born 1977), Australian comedianMatt Jefferies (1921–2003), American artist, set designer and writerRichard Jefferies (1848–1887), English nature writerThomas Jeffries, also known as Thomas Jefferies (died 1826), Australian outlaw & prisoner