On October 1, 1988, Sellers flirted with a no-hitter through 7⅓ innings until Luis Medina of the Cleveland Indians hit a home run accounting for the only run in a 1–0 victory over the Red Sox. He struck out 10 Indians in the losing effort, which turned out to be his last major league appearance.
Before the 1989 season, Sellers was sent by Boston with Todd Benzinger and a minor leaguer to the Cincinnati Reds in the same transaction that brought Nick Esasky and Rob Murphy to the Red Sox. But Sellers suffered an injury the following spring and never played for Cincinnati.
Sellers played high school baseball for Paramount High School, where he was drafted by the Red Sox after graduating in 1982.