In 2000, Goss was made a BBC senior content producer and put in charge of the BBC's official Doctor Who website. Originally the site was part of the BBC's Cult TV website. Goss slowly expanded the content to include Buffy the Vampire Slayer, Farscape, The Simpsons, 24 and Doctor Who. He was subsequently voted Number 19 in TV Cream's 2004 poll of Top 50 Media Movers and Shakers.
With the return of Doctor Who in 2005, the Cult site was slowly wound down in order to concentrate solely on the show. Goss moved to BBC Wales to oversee the production of the new show's web site, expanding the contents to include cast and crew interviews, games and spin-off sites based on the broadcast episodes. His aim was to construct a whole world beyond the show that viewers could get further involved in, notably employing graphic designer Lee Binding for front pages and site design, and writer Joseph Lidster for the spin-off sites' fictional content. Sequence, a Cardiff-based design agency, were also responsible for all of the 2006 Doctor Who series games, experiences and many of the associated websites. Goss also produced the video clip "krill-loop" for a tie-in website.
Having produced previous Doctor Who web only animations (such as Scream of the Shalka) and Shada, in 2005 Goss produced the animations of two missing episodes of The Invasion. The animation, developed by Cosgrove Hall, was originally intended as web-only content but was later added to the DVD release and went on to be voted best DVD special feature in the 2006 Doctor Who Magazine awards.
In 2006, Goss developed and produced The Infinite Quest, a Doctor Who animation shown on BBC One and CBBC in 2007. He was also producer of the special features for the DVD release. He has since produced DVD extra features for further 2 Entertain Doctor Who releases, including The Chase, The Keys of Marinus, The Masque of Mandragora, and The Trial Of A Time Lord.
In 2006, he appeared in an episode of Doctor Who Confidential.
In 2013 Scream of the Shalka was released on DVD with extras which include James Goss presenting a documentary on how the series came to be made and appearing in a documentary about the BBC cult website. He also produced a series of 5 (short) documentaries called Doctor Forever which appeared across Doctor Who DVD Special Edition releases in 2013. He was also involved in producing a series of documentaries for the 50th Anniversary of Doctor Who which in 2013 were first shown on BBC America and subsequently on Watch in the UK.
In 2007, he contributed to the Doctor Who short-story collection Short Trips: Snapshots. His first book, Almost Perfect, a tie-in to the Doctor Who spin-off series Torchwood, was released in October 2008 and was followed by two more Torchwood novels and Bad Blood, a novel based on the TV series Being Human.
Goss's Dead Air, read by David Tennant, was voted 2010 Audiobook Of The Year.
His Eleventh Doctor audiobook The Hounds of Artemis was given away free with a February 2011 issue of The Guardian. It is read by Matt Smith and Clare Corbett. His books Dead of Winter (Doctor Who) and First Born (Torchwood) were both nominated for the 2012 British Fantasy Society Awards. He has written numerous stories produced by Big Finish Productions in their Doctor Who related ranges.
In 2013, BBC Books published Goss's short novel Summer Falls, purportedly written by Doctor Who character Amelia (Pond) Williams. In September 2014 his Doctor Who novel 'Blood Cell' was published (Twelfth Doctor).
In addition to the three Torchwood novels and Doctor Who novels, James Goss is the co-author, with Steve Tribe, of The Dalek Handbook (2011), Doctor Who: A History of the Universe in 100 Objects (2012) and The Doctor: His Lives and Times (2013). In 2014 he contributed to the Shakespeare Notebooks.
In 2015 his novel Haterz, about a man making the internet a better place one murder at a time, was published in the UK by Solaris Books and launched at the Forbidden Planet Megastore in London on 12 March 2015 with a book reading and signing by the author.
In 2016 James Goss's novel, 'What she does next will astound you', which is tied into the TV Series Class, was published.
Having written the novelisation of the Douglas Adams Doctor Who story 'City of Death' in 2015, his novelisation of Douglas Adam's story 'The Pirate Planet' was published in 2017. The audiobook is read by the voice of Tom Baker, Jon Culshaw.
Goss's stage play Dirk, adapted with fellow student Arvind Ethan David from the Douglas Adams book Dirk Gently's Holistic Detective Agency, having been first performed (in its authorised form) in 1995, has been staged around the world. In 2007 it won "Best Adaptation" in the 28th LA Weekly Theater Awards. The play was published in 2016 by Samuel French, Play Publishers.
He wrote the play 7 Spies At The Casino about the making of the 1967 film Casino Royale, which was performed at the Edinburgh Festival Fringe in August 2007.
James Goss has also written a play about the true story of the "terribly nice friendship" between Mr Peter Cushing and Sir Christopher Lee, forged during their Hammer Horror careers (see Hammer Film Productions). The play, called ‘The Gentlemen of Horror’, was first performed on 27 November 2013 at the Woolwich Grand Theatre. It was performed in the summer of 2014 at the Camden Fringe where it received favourable reviews including and
Goss blogged from the Edinburgh Fringe for The Guardian's web site in 2007 and wrote a series of guest blogs about archive television for the AOL UK TV web site in 2009-2010.
As mentioned above, Goss wrote three novels for the Doctor Who spin-off series Torchwood. In addition, in the Torchood range, he wrote four short stories, published in the Torchwood Magazine; two audiobooks, Department X and Ghost Train; and two radio plays both broadcast on BBC radio 4; Golden Age on 2 July 2009 and The House of the Dead on 13 July 2011. In 2015 he became the producer of a new series of Torchwood audio stories to be produced by Big Finish Productions ( Torchwood (Big Finish series) ).
From 2011 to 2012, Goss co-produced with Joseph Lidster, the Big Finish Productions' range of Dark Shadows audio dramas. In 2014 he also produced the New Adventures of Bernice Summerfield for Big Finish Productions.
Goss has written three historical murder mysteries in which the Lady Serpent, an assassin, solves crime, as well as committing it, in Ancient Egypt. These stories are published in e-book format by Endeavour Press.