JWH 359

JWH-359 is a dibenzopyran "classical" cannabinoid drug, which is a potent and selective CB₂ receptor agonist, with a K_i of 13.0nM and selectivity of around 220x for CB₂ over CB₁ receptors. It is related to other dibenzopyran CB₂ agonists such as JWH-133 and L-759,656 but with a chiral side chain which has made it useful in mapping the shape of the CB₂ binding site. It was discovered by, and named after, Dr. John W. Huffman.