CAS Number 824959-81-1 ChemSpider 24617616 Formula C26H27NO | PubChem CID 45270396 ECHA InfoCard 100.233.380 Molar mass 369.498 g/mol | |
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Legal status CA: Schedule II
DE: Anlage II (Prohibited)
Illegal in Sweden, I-N(Poland) | ||
JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB1 Ki 0.69nM) and JWH-182 (CB1 Ki 0.65nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2nM). It was discovered by and named after Dr. John W. Huffman.
JWH-210 may be neurotoxic to animals when administered in high doses.
Legal Status
JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" synthetic cannabis products. The substances JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.
As of October 2015 JWH-210 is a controlled substance in China.