CAS Number 209414-08-4 Formula C25H25NO Molar mass 355.471 g/mol | ChemSpider 24598813 3D model (Jmol) Interactive image | |
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Legal status CA: Schedule II
DE: Anlage II (Prohibited)
UK: Class B
US: Schedule I
Illegal in Sweden, I-N (Poland) | ||
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is the N1-hexyl homologue of the more common synthetic cannabinoid compound JWH-018. Unlike the butyl homologue JWH-073, which is several times weaker than JWH-018, the hexyl homologue is only slightly less potent, although extending the chain one carbon longer to the heptyl homologue JWH-020 results in dramatic loss of activity. These results show that the optimum side chain length for CB1 binding in the naphthoylindole series is the five-carbon pentyl chain, shorter than in the classical cannabinoids where a seven-carbon heptyl chain produces the most potent compounds. This difference is thought to reflect a slightly different binding conformation adopted by the naphthoylindole compounds as compared to the classical cannabinoids, and may be useful in characterising the active site of the CB1 and CB2 receptors.
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China
As of October 2015 JWH-019 is a controlled substance in China.
Poland
In Poland, JWH-019 is I-N (Poland)
Sweden
JWH-019 is illegal in Sweden
UK
JWH-019 is Class B in the United Kingdom.
USA
JWH-019 is a C-I substance, controlled federally in the United States, and it is not intended for human consumption.
JWH-019 is illegal in Virginia.