MedlinePlus a601064 ATC code A03AX10 (WHO) PubChem CID 22297 | Routes of
administration Oral CAS Number 503-01-5 Molar mass 141.254 g/mol | |
 | ||
AHFS/Drugs.com International Drug Names | ||
Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties; that is, it causes constriction (narrowing) of blood vessels (arteries and veins). Along with paracetamol and dichloralphenazone, it is one of the constituents of Amidrine.
Contents
Chemistry
Isometheptene is a monounsaturated aliphatic secondary amine.
Mechanism of action
Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.
References
Isometheptene Wikipedia(Text) CC BY-SA