Isis, in comics, may refer to:
Isis (DC Comics), a comic book character originally featured in the TV show The Secret of Isis
Isis (cat), a cat owned by supervillainess Catwoman that featured in Batman: The Animated Series and Krypto the Superdog
Isis (Bluewater Comics), superhero created by Angel Gate Press and Image Comics
Isis (Marvel Comics), an Egyptian goddess in the Marvel Universe
