Isaac is a given name derived from Judaism and can refer to:
Isaac, one of the patriarchs of the Abrahamic faiths
Isaac (name), including a list of people with the given name or surname of Isaac and its variants
Port Isaac, Cornwall, United Kingdom
Isaac's Harbour, Nova Scotia
Isaac's Harbour North, Nova Scotia
International Society for Augmentative and Alternative Communication (ISAAC)
"Isaac", a song by Madonna, from her album "Confessions on a Dance Floor"
Isaac, the northeasternmost country in the Fire Emblem universe continent Jugdral
Hurricane Isaac (2012), a Category 1 hurricane that hit the Greater New Orleans area on August 29, 2012
Isaac (talk show), a talk show hosted by Isaac Mizrahi
Tropical Storm Isaac, a designation used for various tropical cyclones
ISAAC (cipher), a cryptographically secure pseudorandom number generator
ISAAC (comics), a supercomputer in Marvel Comics
International Study of Asthma and Allergies in Childhood (ISAAC), a global epidemiological study of asthma and allergies in children